HIGH-RESOLUTION AND HIGH-ACCURACY TOPOGRAPHIC AND TRANSCRIPTIONAL MAPS OF THE NUCLEOSOME BARRIER

Nucleosomes represent mechanical and energetic barriers gotrax handlebar that RNA Polymerase II (Pol II) must overcome during transcription.A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II nucleosome crossing dynamics, is still missing.Here, we obtain topographic and tr

The video is available by cutting and pasting mms://media.lib.uoguelph.ca/partnership/DGBLILPartnership.wmv into Windows Media Player.Please contact the section editor if you experience any difficulties or have any questions about proceeding with this submission.This presentation, originally given at WILU in May of 2008 examines the use and creatio